Pregnant women experience additional stress on the body. Undesirable or dangerous conditions often arise that must be corrected. One of the drugs to correct negative situations is papaverine. Next, we’ll talk about what kind of drug it is, in what cases it is used, and what side effects it has.

Prescription of papaverine during pregnancy

Sometimes pregnancy doesn't go entirely smoothly. For various reasons, colic and increased tone may occur. internal organs, spasms. To eliminate symptoms and prevent miscarriage, the drug Papaverine is often used. These are the cases.

1. Colic: bronchial, abdominal, renal, hepatic.
2. Increased tone of internal organs (uterus).
3. Spasms of cerebral and peripheral vessels.
4. Deterioration of respiratory functions.
5. Toxicosis at a late stage.
6. High blood pressure.
7. Poor circulation.
8. Increased risk of miscarriage (spontaneous) and early birth.

Low amount of progesterone(female hormone) in a pregnant woman leads to the risk of miscarriage due to increased tone. The drug relaxes the muscles of the organ and increases its blood supply. Suppositories during pregnancy should be used only as prescribed by a doctor (gynecologist). Typically, three or four suppositories are used per day. The course of treatment can last one and a half months.

Tablets can only be prescribed by a specialist. The course of treatment lasts from one week to fifteen days, three or four pieces per day. When using injections, improvement in well-being is noted fifteen minutes after administration of the drug. The effect of the injections lasts only two or three hours. But the action happens quickly. Spasms decrease, rapid heartbeat and nervousness disappear, and pulse improves. Intramuscular injections can be done at home, but intravenously only in a clinic.

Effect of the drug

Papaverine for pregnant women is myotropic antispasmodic, blood pressure lowering and vasodilator. Refers to vasolidators - agents that reduce the tone of the walls (venous). The product is intended to eliminate problems of the gastrointestinal, reproductive, and urinary systems. In high concentrations of the drug in the body, a calming effect is achieved, a decrease in vascular tone, increased heart activity, relaxation of the muscles of the respiratory, reproductive, gastrointestinal, and urinary systems . The drug exhibits the following activity:

Composition release form

The drug for pregnant women is produced and supplied to the pharmacy chain in tablets, rectal suppositories and in the form of a solution for injections. White bitter tablets are odorless. Weighing 0.04 grams, 0.01 grams. The main substance is papaverine hydrochloride. Additional substances: potato starch, sugar, talc, stearic acid. Packed in contour blisters of ten tablets per cell.

Papaverine suppositories during pregnancy contain the main substance papaverine hydrochloride and auxiliary components: solid fat, emulsifier, cosmetic stearin. Suppositories with papaverine during pregnancy weighing 0.02 grams (each candle) are packaged in blisters made of aluminum or polyvinyl chloride foil, in cardboard boxes with a gasket containing ten candles. The injection solution contains the main substance papaverine hydrochloride weighing 20 micrograms per milliliter of solution. Additional components are: water for injections, methionine D, L, disodium edetate.

Contraindications

The drug is contraindicated in the following cases:

The product should not be used without prior consultation with specialists. Intravenous injections are performed only medical workers in the hospital. The drug is not prescribed in the following cases:

• tachycardia;
• liver diseases (liver failure in severe);
• glaucoma;
• hypersensitivity to the drug;
• thyroid diseases;
• reflux gastroesophageal disease;
• intraocular pressure.

Also, the drug is not prescribed to children under six years of age, the elderly, or those with heart failure. Consultation and observation of a doctor is required for the following conditions:

• decreased amount of thyroid hormones (hypothyroidism);
• post-traumatic (craniocerebral);
• benign neoplasm in the prostate (hyperplasia);
• supraventricular tachycardia;
• chronic renal failure;
• conditions in which shock and loss of consciousness are observed;
• problems with the adrenal glands.

Negative manifestations

In case of overdose, gastric lavage is performed. The use of activated carbon, milk and the removal of toxic substances (hemodialysis) is recommended.

Compatibility with other drugs

When using the drug, you must take into account the fact that some drugs used together enhance or weaken its effect. Antidepressants may reduce blood pressure even more. For example, quinidine, procainomide or reserpine. Reduces the hypotensive effect of Methylpod. Drugs based on barbituric acid, which have a depressant effect on the central nervous system, increase the antispasmodic effect. The effect of drugs that increase the amount of dopamine in the central nervous system (Levopoda) is reduced. Priapism may develop with the use of alprostadil. Alcohol-containing drugs should be excluded.

Some women expecting a baby experience uterine hypertonicity. Medicinal suppositories with papaverine, which are often prescribed during pregnancy, will help cope with this problem.

Beneficial properties of the drug

When expecting a baby, muscle spasms often occur; they are eliminated with the help of a special sex hormone - progesterone. If the body lacks this important hormone, the risk of miscarriage increases. In such cases, the fair sex is diagnosed with “hypertonicity of the uterus.” In order to improve a woman’s well-being, she must additionally take medications containing progesterone.

To reduce the tone of the uterus, a doctor may prescribe papaverine to a pregnant woman.

You can relieve spasms that occur in smooth muscles with the help of Papaverine. So what beneficial properties suppositories with papaverine during pregnancy have: why is this drug prescribed? It is endowed with antispasmodic properties. The medication helps with high blood pressure and improves blood circulation in the area of ​​the reproductive organs.

Rectal suppositories do not have a negative effect on the unborn baby.

The medicine is also endowed with calming properties; it also helps with increasing heart rate.

Is it allowed to inject Papaverine at home on your own?

Papaverine is produced in a variety of dosage forms. Typically, representatives of the fair sex are prescribed suppositories, but sometimes expectant mothers are also prescribed injections with a medicinal solution. At home, it is allowed to give Papaverine injections intramuscularly.

It is necessary to strictly follow the dosage established in the instructions: if the recommended dose is exceeded, unwanted side effects occur.

When using papaverine injections, you must strictly follow the instructions.

A pregnant woman develops an allergic rash, her blood pressure drops sharply, and severe drowsiness or nausea may occur. When introduced into the body too large quantity When taking the drug, intestinal function is also disrupted, and problems with bowel movements (constipation) are observed. If a doctor has prescribed Papaverine injections into a vein for a pregnant woman, they must be given in the hospital: the medication is administered very carefully and slowly.

Is it permissible to use rectal suppositories in the first three months of pregnancy?

Papaverine can be used in the first trimester of pregnancy

But if the doctor prescribed suppositories containing papaverine to a pregnant woman, there is no need to worry. You should not stop using suppositories with papaverine: the instructions indicate that this medicine does not harm the unborn child.

Use of the drug in the second and third trimester of pregnancy

In the second trimester, suppositories are used for pain in the abdominal area and increased blood pressure. During this period, Papaverine is used in combination with other medications. The dosage of the medicine is determined by a specialist. Usually one suppository is inserted per day.

In the third trimester, rectal suppositories are used for the following purposes:

• Relieving pain in the abdominal area;
• Preparing the cervix for the upcoming birth;
• Relief of pain that occurs during contractions.

Side effects of the drug

Papaverine suppositories are compact in size; the expectant mother can insert them into the anus on her own. The medicine begins to act quite quickly: almost immediately after the suppository dissolves. When using medicinal suppositories, you need to drink a large amount of liquid, in this case the medicine reaches its destination faster.

When using the medication, the following side effects may occur:

• Redness on the skin;
• Nausea;
• Reduced pressure;
• Increased number of eosinophils in the blood;
• Lethargy, fatigue.

But these undesirable effects occur quite rarely. This drug is usually well tolerated by women. It can be used for a long time.

Contraindications to the use of the drug

Suppositories with papaverine should not be used in the presence of severe liver pathologies or individual sensitivity to the components of the product.

Caution should be exercised when using suppositories if the expectant mother has had a traumatic brain injury in the past or has serious kidney disease or tachycardia.

When treating with drugs containing papaverine, you need to give up alcoholic beverages and cigarettes.

No-shpa as an analogue of Papaverine

The composition of the drug No-shpa includes drotaverine hydrochloride. The drug is also endowed with antispasmodic and sedative properties. No-shpa is often prescribed to pregnant women. It reduces the tone of the uterine muscles, reducing the likelihood of premature termination of pregnancy. No-shpa is used as an anesthetic for headaches and cramps in the abdominal area.

No-spa has antispasmodic properties

Before using this medicine, you should consult your doctor. The drug should not be used in case of low blood pressure, atherosclerosis of the coronary arteries, severe kidney disease, or individual sensitivity to the components of the drug.

Drugs with an antispasmodic effect can alleviate the condition of the expectant mother. They normalize the functioning of the cardiovascular system and reduce heart rate.

Unfortunately, now every second woman who is expecting the birth of a baby is faced with increased uterine tone. This condition is very dangerous because it can disrupt the pregnancy and lead to miscarriage. The diagnosis is especially dangerous during pregnancy.

What is this medicinal product, whether it is dangerous for the baby, and what indications and contraindications it has, we will look into the article in more detail.

Smooth muscle spasms are quite common during pregnancy. They appear as a result of the production of the hormone progesterone in the body, which is responsible for ensuring that a woman carries and gives birth to a healthy child.

However, in some situations, insufficient amounts of this hormone are produced. As a result, there is a threat of miscarriage or premature birth, depending on the period. That is why it is quite dangerous.

In order to deal with the problem and minimize the risk of miscarriage, the woman is prescribed an additional dose of the hormone, which she will receive from medications.

Papaverine has a whole list of actions:

1. A gradual, gentle decrease, which often increases in pregnant women due to an increase in blood volume in the body.
2. Complete relaxation of the muscles of all internal organs.
3. Improved blood supply to the uterus, which has a positive effect on the course of pregnancy.
4. When taking large dosages, an excellent sedative effect is felt, the heart rate decreases, the nervous system calms down and the psycho-emotional state returns to normal.

Papaverine - excellent remedy to prevent miscarriages early stages.

As you can see, the spectrum of action of the drug is very wide, it helps to solve most of the problems that arise for a pregnant woman, and at the same time is completely harmless to the fetus.

Application of Papaverine injections

Papaverine - effective remedy with uterine tone

After examining and conducting a series of tests, the gynecologist will be able to draw a conclusion about the severity of your condition, and based on this, prescribe exactly how you will need to take Papaverine.

The drug is available in the form of suppositories and liquid for injections.

Injections are divided into 3 types:

1. Intravenous injections. If you have been prescribed to inject Papaverine into a vein, then this should only be done in a clinic. The medicine must be administered as slowly as possible, and doing such injections at home is simply dangerous.
2. Intramuscular injections. These injections can also be done at home. You can inject into different muscles, but the gluteal region is most often chosen.
3. Subcutaneous injections.

Only a doctor can determine exactly how to inject the drug. Self-prescribing medication is prohibited.

Side effects

In addition to a large number positive aspects Papaverine also has side effects that you need to be aware of.

These include:

• on the components of the drug
• Lower blood pressure
• Difficulty defecating
• When a large amount of the drug is administered, a constant craving for sleep may occur.
• Nausea and dizziness
• Increased sweating
• Constipation
• If the drug is injected into a vein quickly enough, heart palpitations may occur.

But, in most women, the body does not suffer from side effects and therefore papaverine in injections is successfully used by pregnant women.

Despite the fact that the medicine sometimes negatively affects the mother’s body, Papaverine is well tolerated by the child and does not cause him any harm. This has already been tested by many pregnant women and decades of use.

Contraindications to the use of the drug

You should know that for some pregnant women Papaverine is a dangerous and therefore prohibited drug.

These include women who have problems with the functioning of the thyroid gland, liver problems, constant elevated intraocular blood pressure, and tachycardia.

The drug should not be used independently, without a doctor’s prescription.

Remember, the appearance of uterine hypertonicity must be treated comprehensively; Papaverine alone cannot do it. To know what other medications can help maintain your pregnancy, you need to be examined by a specialist. Only he will prescribe the correct set of medications.

You can alleviate your condition with hypertension not only by using medications. There are several more solutions:

• Watch your lifestyle
• Don't overexert yourself, remember that you are pregnant, take care of yourself.
• Get more rest
• Don’t be nervous, the load on the nervous system immediately provokes muscle tone in the body.
• Get outdoors more often. The perfect solution– slow walks in a park or square.

Papaverine is an excellent drug that helps relax the smooth muscles of the uterus and remove the threat of premature birth or. Remember, this drug must be prescribed to you by your gynecologist. Self-administration of the drug is unacceptable.

More about the drug in the video:

• 
• Suppositories with Papaverine during pregnancy. Is it possible to relieve the spasm...

Many pregnant women try to refrain from taking any medications for fear of harming the baby. However, uterine hypertonicity is not one of those conditions that can be ignored. Excessive muscle activity during pregnancy often leads to miscarriage or premature birth. To avoid such troubles, doctors prescribe suppositories with papaverine to women. It is believed that this drug does not harm the child and the mother, despite the fact that clinical studies have not been conducted on its safety during pregnancy.

Is papaverine hydrochloride harmful during pregnancy?

The instructions for the drug state that no clinical studies have been conducted on its effects on the body of expectant mothers, therefore it is contraindicated during pregnancy. However, the situation is not so clear-cut.

Medicines based on papaverine have been successfully used for six decades. During this time, the medicine was used by several generations of pregnant women, who gave birth to more than one million absolutely healthy babies.

Thus, long-term observations of obstetricians-gynecologists and pediatricians show that rectal suppositories with papaverine, when indicated and used appropriately, have a positive effect on the condition of expectant mothers and do not affect the intrauterine development of the fetus.

Composition and action of rectal suppositories

The action of papaverine is based on relaxation of the smooth muscles of internal organs: stomach, intestines, bronchi, lungs, blood vessels and uterus. The relaxing effect does not apply to the striated muscles, which means that the muscles of the skeleton and heart will work as before.

Papaverine was first isolated in the mid-19th century from the opium poppy. This alkaloid gained significant popularity in the fifties of the last century, when its industrial production was established.

Thus, papaverine suppositories have a complex effect on the female body:

• relieve excessive tone and suppress contractions of the uterus and other muscle organs;
• have a vasodilating effect;
• lower blood pressure.

Papaverine suppositories are the most effective form of medicine for pregnant women

In addition to suppositories, many manufacturers produce papaverine hydrochloride preparations in the form of tablets and solutions for intravenous administration. However, doctors most often prescribe rectal suppositories to pregnant women, considering them a safer and more effective dosage form.

Indications

Due to hormonal changes in the female body during pregnancy, the amount of progesterone, a hormone involved in muscle relaxation, decreases. As a result of this, the uterus can actively contract and even be constantly in increased tone. This condition is a serious threat to the development and life of the fetus. Typically, papaverine suppositories are prescribed to pregnant women with high uterine tone, threatening spontaneous miscarriage or premature birth.

In addition, doctors prescribe this antispasmodic for complex treatment conditions such as:

• inflammation of the gallbladder;
• renal colic;
• diseases gastrointestinal tract(colitis, flatulence, functional intestinal disorders);
• inflammation of the urinary tract (urethritis and cystitis);
• gestosis (complication of pregnancy, accompanied by swelling, cramps, high blood pressure).

Suppositories with papaverine also have a sedative effect and normalize heart rate. However, such an effect is observed only after prolonged use of the drug.

Contraindications

Medicines containing papaverine in any dosage forms are prohibited for diseases and conditions such as:

• intolerance to the components of the drug;
• atrioventricular block (heart rhythm disturbances);
• liver failure;
• increased intraocular pressure.

Papaverine suppositories should be used with extreme caution in women who have been diagnosed with hypothyroidism, tachycardia, and disorders of the adrenal glands and kidneys. You should definitely report these problems to your doctor.

Constipation and other possible side effects

Undesirable consequences from taking suppositories with papaverine are quite rare and, as a rule, depend on individual characteristics pregnant woman. Side effects include:

• allergic reactions;
• nausea;
• drowsiness;
• bowel dysfunction (constipation);
• increased sweating;
• arterial hypotension (low blood pressure).

Low blood pressure is one of the possible side effects when taking suppositories with papaverine

Taking the drug by trimester

Typically, suppositories with papaverine are not used separately. Depending on the trimester and the severity of the disease, this antispasmodic is often prescribed in combination with other medications.

First trimester

At the beginning of pregnancy, the list of safe medications is very limited due to the immature placenta. Meanwhile, papaverine is in great demand as an antispasmodic.

In the first weeks of pregnancy, some women suffer from uterine hypertonicity associated with poor progesterone production.

That is why papaverine is prescribed along with hormonal medications.

Second trimester

During this period, the list of approved drugs is significantly expanded. In case of hypertonicity, threat of miscarriage, doctors prescribe more serious medications that inhibit the contractile activity of the uterus - for example, Ginipral, Bricanil or magnesium injections. Papaverine suppositories in the second trimester are most often used to relieve pain

for renal colic, for diseases of the gastrointestinal tract and urinary system, accompanied by spasms, as well as to reduce blood pressure.

Third trimester On later

1. During pregnancy, rectal suppositories with papaverine are prescribed in the following situations:
2. Before childbirth, suppositories are used as indicators of “false” contractions. If after administration of the drug the contractile activity of the uterus has stopped, it means that labor has not yet occurred.
3. At 39 weeks of pregnancy, suppositories are used to prepare the cervix for labor.
4. During real contractions, the drug is prescribed to reduce pain.

Instructions for safe use

Suppositories with papaverine during pregnancy are prescribed only by the attending doctor after a full examination and clarification of the diagnosis. He also determines the dosage and duration of the course of therapy.

Pregnant women are usually prescribed one papaverine suppository several times a day at regular intervals. They are inserted into the rectum while lying on the side. This must be done with clean hands or sterile gloves to avoid pathogenic microbes entering the body.

The action of the active substance begins almost immediately after the dissolution of the rectal suppository. But for a lasting effect, you need to complete the full course of treatment prescribed by your doctor. Sometimes it can be quite long (up to a month).

How can you replace suppositories with papaverine, including in the early stages?

Papaverine in the form of rectal suppositories does not have analogue drugs containing the same active ingredient. If a woman is intolerant to papaverine, the doctor may prescribe antispasmodic medications that contain other active ingredients, but have a similar therapeutic effect.

A substitute for papaverine suppositories are preparations consisting of several active components, one of which is papaverine.

Table: papaverine analogues prescribed during pregnancy

Name	Dosage forms	Active substance	Indications	Contraindications	Use during pregnancy
	Pills; solution.	Drotaverine hydrochloride	Renal colic; biliary colic; intestinal colic; spastic constipation; endarteritis; uterine spasms, threatening premature birth and miscarriage.	Intolerance to components; cardiogenic shock; arterial hypotension; glaucoma; severe renal and liver failure.	According to the doctor's indications
	Solution; pills.	Drotaverine hydrochloride	Hypertonicity of the uterus; spasms of smooth muscles in diseases of the biliary tract; spasms of smooth muscles of the urinary system; spasms of the gastrointestinal tract; headache.	Severe renal failure; severe liver failure; severe heart failure; hypersensitivity to the drug; galactose intolerance.	According to the doctor's indications
	Pills	Papaverine hydrochloride; Dibazol.	Arterial hypertension; spasms of peripheral arteries and cerebral vessels; spasm of smooth muscles of internal organs; polio.	Disturbances in the conduction system of the heart; epilepsy; intolerance to components.	Allowed with caution
	Pills; solution; concentrate.	Hexoprenaline sulfate	Hypertonicity of the uterus; inhibition of labor contractions during childbirth; prevention of premature birth.	Thyrotoxicosis; tachyarrhythmia; myocarditis; arterial hypertension; cardiac ischemia; severe kidney and liver diseases; angle-closure glaucoma; intrauterine infection; hypersensitivity to components.	Can be used from the second trimester

Photo gallery: antispasmodic drugs used during pregnancy

No-spa is a popular drug for relieving cramps, including in pregnant women.
Drotaverine is a synthetic drug that reduces the tone of smooth muscles of internal organs and helps reduce pain during spasms of various organs Ginipral is a drug that helps reduce the tone and contractile activity of the uterus Papazole, like papaverine suppositories, contains papaverine hydrochloride

Medicines during pregnancy can only be used as prescribed by a doctor. This also applies to taking Papaverine during pregnancy. The medication has strict indications and contraindications and possible side effects.

Papaverine is an antispasmodic whose action is aimed at relaxing smooth muscles. The mechanism is to accelerate the passage of calcium ions through the muscles. During pregnancy, the medicine is indicated for. Not dangerous for women and fetuses.

When prescribing a large dosage, sedation is possible. It is eliminated from the body after two hours.

The drug is presented in the form:

• tablets;
• ampoules for injection;
• suppositories for rectal administration.

Indications for use

Why is Papaverine prescribed to pregnant women? The indications are as follows:

• Increased and threat of miscarriage. The most common reason for prescribing medication. In severe conditions and to preserve the fetus, injections or drops are prescribed.
• Arterial hypertension. In pregnant women, pathology can be a consequence or be an independent disease. Taking Papaverine reduces blood pressure and does not have a negative effect on the child.
• Bronchospasm. When taking the drug, the bronchi relax, breathing problems are eliminated and health improves.
• Renal, intestinal or hepatic colic. Eliminates spasm and pain. As a result, the function of the affected organ is normalized.

Uterine tone - indication for the use of Papaverine

Papaverine during pregnancy

The regimen for taking Papaverine during pregnancy is prescribed by the attending physician. Pathology and duration are taken into account.

In the first trimester

Suppositories with Papaverine during pregnancy are prescribed in the early stages, in the first trimester. Indications: uterine hypertonicity. It should not be used without a doctor's indication, as it may lead to adverse consequences.

If there is a threat of miscarriage, Papaverine is prescribed in the form of injections. In other situations, suppositories are prescribed in the early stages.

Suppositories with Papaverine during early pregnancy are used in case of increased uterine tone. You should not start using the drug without a medical prescription, so as not to provoke side effects. The advantage of rectal suppositories is their high bioavailability and long-lasting effect.

In the second trimester

In the second trimester, the drug is more often prescribed in the form of suppositories if there are indications - abdominal pain, high blood pressure.

Taking Papaverine can be supplemented with other drugs, depending on the symptoms and clinic.

In the third trimester

In the later stages, Papaverine is most often prescribed for uterine hypertonicity. Closer to the date of birth, the indication is to prepare the cervix for dilatation. At the onset of labor, the medicine effectively reduces pain during contractions in a pregnant woman.

Video about increased uterine tone

Instructions for use

Features of the use of Papaverine depend on the reason for prescribing the drug, symptoms, stage of pregnancy and the condition of the woman.

Candles

Where are Papaverine suppositories inserted during pregnancy? This form of medication is rectal, which means that suppositories are inserted into the rectum. The body temperature is sufficient to dissolve the suppository and the active substance from it penetrates into the blood.

To administer a suppository, the procedure is as follows:

• Wash your hands with soap and wipe dry.
• Remove the candle from the packaging.
• Lie on either side, slightly raise the leg on top, and insert a candle into the anus.
• Lie at rest for a few minutes so that the suppository dissolves in the rectum.

Dosage of the drug – 1 suppository twice or thrice a day. Course duration is up to 21 days. All this is determined by the attending doctor.

Pills

Papaverine tablets are intended for oral use. They lower blood pressure, relax smooth muscles and act as an antispasmodic.

The dosage is individual, on average 3 or 4 tablets per day. Course duration is 7-14 days.

In the third trimester, tablets can be prescribed for increased heart rate and slight increase in blood pressure, in the absence of gestosis. For uterine tone, Papaverine is prescribed only in combination with other medications. Treatment tactics are the prerogative of the doctor. Self-medication is unacceptable.

Injections

Papaverine injections during pregnancy act quickly, so they are prescribed more often in emergency situations. The active substance acts for several hours, so injections are given approximately 4 times a day.

Contraindications

There are the following contraindications for taking Papaverine:

• Heart rhythm disturbances.
• Atrioventricular block.
• Kidney or liver failure.
• Thyroid diseases.
• Increased intraocular pressure.
• Individual intolerance to the components of the drug.

Possible side effects

When using suppositories with papaverine hydrochloride at home, the following side effects are possible:

• heart rhythm disturbance;
• dizziness;
• decrease in blood pressure below normal;
• nausea and vomiting;
• increased drowsiness;
• allergic reactions.

If any side effects occur, you must contact the clinic.

Papaverine during pregnancy is an effective remedy for uterine hypertonicity, high blood pressure and other pathological conditions. According to women's reviews, the medicine significantly improves their well-being. The dosage and form of the drug are prescribed only by a doctor.